{"id":1258,"date":"2015-12-28T18:31:48","date_gmt":"2015-12-28T18:31:48","guid":{"rendered":"http:\/\/www.uphill.cat\/blog\/?p=1258"},"modified":"2015-12-28T18:31:48","modified_gmt":"2015-12-28T18:31:48","slug":"tolerancia","status":"publish","type":"post","link":"https:\/\/www.uphill.cat\/blog\/tolerancia\/","title":{"rendered":"Toler\u00e0ncia"},"content":{"rendered":"<p>La major part de les subst\u00e0ncies que produeixen depend\u00e8ncia, tenen a m\u00e9s com<\/p>\n<p>caracter\u00edstica la capacitat de produir toler\u00e0ncia.<\/p>\n<p>La toler\u00e0ncia es defineix com un estat d&#8217;adaptaci\u00f3 que es caracteritza per la disminuci\u00f3 de les respostes a la mateixa quantitat de droga, o necessitat de dosis majors per produir el mateix grau d&#8217;efecte farmacodin\u00e0mic.<\/p>\n<p>El fenomen de toler\u00e0ncia es pot explicar de manera diferent segons els tipus de subst\u00e0ncia. En general hi ha dos tipus de toler\u00e0ncia adquirida, deixant a part la innata, que s\u00f3n:<\/p>\n<p>La toler\u00e0ncia disposicional:<\/p>\n<p>Aquesta toler\u00e0ncia a les drogues es produeix per canvis metab\u00f2lics amb el resultat de menor quantitat de la mateixa en el lloc espec\u00edfic d&#8217;actuaci\u00f3. Aquest tipus de toler\u00e0ncia es produeix en l&#8217;alcohol i en aquest cas \u00e9s el fetge l&#8217;encarregat de la metabolitzaci\u00f3 de la subst\u00e0ncia activa amb el resultat d&#8217;una disminuci\u00f3 en l&#8217;\u00f2rgan diana, \u00e9s a dir en el sistema nervi\u00f3s central.<\/p>\n<p>La toler\u00e0ncia farmacodin\u00e0mica:<\/p>\n<p>En el cas de la toler\u00e0ncia farmacodin\u00e0mica es produeixen canvis adaptatius dins dels sistemes afectats, de manera que la resposta \u00e9s menor en pres\u00e8ncia de la mateixa quantitat de subst\u00e0ncia.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>La major part de les subst\u00e0ncies que produeixen depend\u00e8ncia, tenen a m\u00e9s com caracter\u00edstica la capacitat de produir toler\u00e0ncia. La toler\u00e0ncia es defineix com un estat d&#8217;adaptaci\u00f3 que es caracteritza per la disminuci\u00f3 de les respostes a la mateixa quantitat de droga, o necessitat de dosis majors per produir el mateix grau d&#8217;efecte farmacodin\u00e0mic. El [&hellip;]<\/p>\n","protected":false},"author":3,"featured_media":1260,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_et_pb_use_builder":"","_et_pb_old_content":"","_et_gb_content_width":"","wp_popup_display_lightbox":0,"wp_popup_suppress":"","wp_popup_trigger":"","wp_popup_trigger_amount":0,"wp_popup_disable_on_mobile":false,"footnotes":""},"categories":[1],"tags":[],"class_list":["post-1258","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-blog"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.9 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Toler\u00e0ncia - UPHILL<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.uphill.cat\/blog\/tolerancia\/\" \/>\n<meta property=\"og:locale\" content=\"ca_ES\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Toler\u00e0ncia - UPHILL\" \/>\n<meta property=\"og:description\" content=\"La major part de les subst\u00e0ncies que produeixen depend\u00e8ncia, tenen a m\u00e9s com caracter\u00edstica la capacitat de produir toler\u00e0ncia. 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